Herrera miranda g, ramos aguila y, mujica gonzalez d, gutierrez perez m. Report of one case by balduin lawson p and jorge silva c. Several cases of hyperglycaemia and ketoacidosis associated with alterations in sodium levels 1,4 have been reported in recent years, suggesting that hyperglycaemia associated with hyponatraemia should be added to the list of risk factors alcoholism, malnutrition, etc. There is a controversy wheter central pontine myelinolysis can complicate either hyponatremia or its rapid correction. Started in 1995, this collection now contains 6767 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. As such the condition is described in the osmotic demyelination syndrome article. Pontine and extrapontine myelinolysis are usually due to a rapid correction of hyponatraemia. Extrapontine myelinolysis radiology reference article. Landi f, dopazo c, sapisochin g, beisani m, blanco l, caralt m, balsells j, charco r. One of the well recognized stimuli for central pontine myelinosis cpm is the rapid correction of chronic hyponatraemia. Parkinsonismo secundario a mielinolisis extrapontina.
Pdf hyponatraemia, pontine myelinolysis and rhabdomyolysis. Conventionally this has been perceived to lead to pontine glial cell swelling through osmosis and eventually to cell death. Pontine and extrapontine myelinolysis secondary to glycemic. Sequential observation of movements disorders and brain images in the case of central pontine myelinolisis and extrapontine myelinolsis. Mielinolisis extrapontina en paciente con hipernatremia. Mielinolisis extrapontina secundaria a hiponatremia por. Mielinolisis extrapontina secundaria a hiponatremia por crisis. Hospital general regional 110 imss university of arizona. Extrapontine myelinolysis epm is one of the complications occurring secondary to rapid correction of hyponatremia, and is, along with central pontine myelinolysis encompassed by the more recent term osmotic demyelination syndrome in the vast majority of cases it is associated with central pontine myelinolysis but it can also rarely occur as an isolated entity. A sezze limpegno di alcuni privati cittadini, del comune e della croce rossa. Central pontine myelinolysis cpm is the most severe neurological complication after liver transplantation and apparently is not related to changes in osmolarity.
Central pontine myelinolysis cpm is a neurological condition involving severe damage to the myelin sheath of nerve cells in the pons an area of the brainstem. L i q u i d o e x t r a c e l u l a r 3040% del peso corporal total. Respuesta auditiva provocada del tronco encefalico baer. Sindrome neuroleptico maligno con mielinolisis central pontina. Mielinolisis pontina central e hiponatremia perioperatoria. Chronic alcoholism or rapid correction of hyponatremia was present in over 75% of cases. August 2015 galina kirovanedyalkova central pontine myelinolysis cpm is heterogeneous group of demyelinating conditions with different etiology, pathophysiological mechanisms, clinical. Pdf central pontine myelinolysis is a demyelinating lesion in the basis pontis which in most cases is caused by a rapid correction of hyponatremia. Conventionally this has been perceived to lead to pontine glial cell swelling through. Central pontine myelinolysis cpm is now more commonly referred to as osmotic demyelination syndrome, which recognizes that the same phenomenon is also seen in other areas of the brain previously known as extrapontine myelinolysis. It is predominately iatrogenic treatmentinduced, and is characterized by acute paralysis, dysphagia difficulty swallowing, dysarthria difficulty speaking, and other neurological symptoms. Antemortem computed tomography ct had been performed in nine, and ante or postmortem magnetic resonance mr imaging in 11. Extrapontine myelinolysis is an acute unusual process, included in demyelinating syndromes of metabolic etiology, which differentiate from central pontine myelinolysis, by affecting other brain areas with clinical manifestation such as dystonia, catatonia, postural tremor, myoclonic spasm, parkinsonism or pyramidal sings. Hiponatremia en pediatria sodio especialidades medicas.
1419 1068 1632 991 1507 711 118 1349 1018 1238 782 1415 244 195 1178 1172 1263 1513 1657 831 72 64 1169 655 982 1177 759 254 1441 1259 492